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Poly(ADP-Ribose) Polymerase Inhibition as a Model for Synthetic Lethality in Developing Radiation Oncology Targets

โœ Scribed by Anthony J. Chalmers; Mina Lakshman; Norman Chan; Robert G. Bristow


Book ID
113900789
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
581 KB
Volume
20
Category
Article
ISSN
1532-9461

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โœ Viatcheslav A. Soldatenkov; Mark Smulson ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 301 KB

Poly(ADP-ribose) polymerase (PARP) catalyzes the transfer of successive units of ADP-ribose moiety from NAD ุ‰ covalently to itself and other nuclear acceptor proteins. PARP is a zinc finger-containing protein, allowing the enzyme to bind to either double-or single-strand DNA breaks without any appar