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Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation

✍ Scribed by Fernet, V. Ponette, E. Deniaud-Alex, M.

Book ID: 125545114
Publisher: Informa plc
Year: 2000
Tongue: English
Weight: 243 KB
Volume: 76
Category: Article
ISSN: 0955-3002
DOI: 10.1080/09553000050201118

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## Abstract Inactivation of poly(ADP‐ribose) polymerase‐1 (PARP‐1) has been shown to potentiate the cytotoxicity of distinct DNA targeting agents including topoisomerase I inhibitors. On the other hand, the PARP‐1 deficient cells exhibited resistance to conventional inhibitors of topoisomerase II s