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Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response

✍ Scribed by Fumiaki Watanabe; Hidesuke Fukazawa; Mitsuko Masutani; Hiroshi Suzuki; Hirobumi Teraoka; Shuki Mizutani; Yoshimasa Uehara


Book ID
116288536
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
304 KB
Volume
319
Category
Article
ISSN
0006-291X

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Poly(ADP-ribose) polymerase in DNA damag
✍ Viatcheslav A. Soldatenkov; Mark Smulson πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 French βš– 301 KB

Poly(ADP-ribose) polymerase (PARP) catalyzes the transfer of successive units of ADP-ribose moiety from NAD Ψ‰ covalently to itself and other nuclear acceptor proteins. PARP is a zinc finger-containing protein, allowing the enzyme to bind to either double-or single-strand DNA breaks without any appar