The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid Ξ² (AΞ²) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human AΞ² precursor
β¦ LIBER β¦
Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease
β Scribed by Strosznajder, Joanna B.; Czapski, Grzegorz A.; Adamczyk, Agata; Strosznajder, Robert P.
- Book ID
- 111872616
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 204 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0893-7648
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## Abstract Amyloid peptide is thought to play a critical role in neuronal death in Alzheimer's disease (AD), most likely through oxidative stress. Free radicalβrelated injury leads to DNA breaks, which subsequently activates the repair enzyme poly(ADPβribose) polymeraseβ1 (PARPβ1). In this study,
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