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Poly(ADP-ribose) effectively competes with DNA for histone H4 binding

✍ Scribed by Georg Sauermann; Jozefa Wesierska-Gadek


Book ID
117056854
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
302 KB
Volume
139
Category
Article
ISSN
0006-291X

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## Abstract We investigated the physical association of the DNA topoisomerase IIΞ² binding protein 1 (TopBP1), involved in DNA replication and repair but also in regulation of apoptosis, with poly(ADP‐ribose) polymerase‐1 (PARP‐1). This enzyme plays a crucial role in DNA repair and interacts with ma