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Poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer

✍ Scribed by Heitmann, Jana; Geeleher, Paul; Zuo, Zhixiang; Weichselbaum, Ralph R.; Vokes, Everett E.; Fetscher, Sebastian; Seiwert, Tanguy Y.

Book ID
125861316
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
950 KB
Volume
50
Category
Article
ISSN
1368-8375

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## Abstract ## Background In this study, we tested the ability of a novel poly(adenosine diphosphate ribose) polymerase (PARP) inhibitor, 10‐(4‐methyl‐piperazin‐1‐ylmethyl)‐2__H__‐7‐oxa‐1,2‐diaza‐benzo[__de__]‐anthracen‐3‐one (GPI‐15427), to enhance the effect of radiotherapy in a xenograft model