Polarographic reduction of pyrithioxine in aqueous buffers containing 5% of ethanol

✍ Scribed by J.M. Lopez Fonseca; M.L. Perez del Molino

• Publisher: Elsevier Science
• Year: 1983
• Tongue: English
• Weight: 571 KB
• Volume: 28
• Category: Article
• ISSN: 0013-4686
• DOI: 10.1016/0013-4686(83)85138-x

✦ Synopsis

The electroreduction of the cerebral metabolism activator pyrithioxine [3 3'-(dithio dimethylen) bls J-hydroxy 6-methyl 4-pyridine methanol] was studied by dc and dp polarography in boric acid-free aqueous buffers containing 5 "/ of ethanol. Over the pH range Z&9.0, one wave, A, or two waves, B and A, were obtained depending on the pyrithiaxine concentration. B is characterized as a "main wave" and A as a Brdicka adsorption post-wave. At pH > 10, two waves, A' and B', were obtained, A' displaying an adsorption-kinetic character.

The mechanism of the electrode process in both pH ranges has been deduced from the dependence of the wave characteristics upon pH and from the results obtained by scan-direct and scan-reversal normal pulse polarography, cyclic voltammetry and UC spectroscopy.