Polarographic investigation of some 4-arylhydrazono-2-isoxazoline-5-ones

✍ Scribed by Bina Jain; S.N. Tandon; R.N. Goyal

• Publisher: Elsevier Science
• Year: 1979
• Tongue: English
• Weight: 253 KB
• Volume: 24
• Category: Article
• ISSN: 0013-4686
• DOI: 10.1016/0013-4686(79)85019-7

✦ Synopsis

The polarographic reduction behaviour of 4-arylhydrazon~2-ioxazoline-S-onus has been investigated to find out the existing tautomeric form. The behaviour suggests the presence of hydruzo form. The effect of various suhstituents on reduction has been studied and a quantitative relationship established between E,,, and Hammett substituent constant. INTUODUffION A number of isoxazoles[1,2] and isoxazolines[3-6] have been reported in the literature to possess considerable hypoglycemic activity. Recently some 4arylhydrazono-Z-isoxazohne-5-ones have been synthesized in this laboratory and their activity reported[7]. These compounds can exist in the following four tautomeric forms: R