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Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers

✍ Scribed by Pierre Wils; Véronique Phung-Ba; Armelle Warnery; Delphine Lechardeur; Shamsi Raeissi; Ismael J. Hidalgo; Daniel Scherman


Book ID
115784179
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
358 KB
Volume
48
Category
Article
ISSN
0006-2952

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The objective of this study was to investigate the mechanisms by which berberine is transported in the secretory and absorptive directions across Caco-2 cell monolayers. The basolateral-to-apical (B-A) flux was 30-fold greater than the apical-to-basolateral flux and temperature dependent (i.e., dras