Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia
β Scribed by Valeri Vasioukhin; Philippe Anker; Pierre Maurice; Jacqueline Lyautey; Christine Lederrey; Maurice Stroun
- Book ID
- 114713634
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 537 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0007-1048
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## Abstract ## BACKGROUND It has been reported that point mutations of the ras gene occur frequently in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). However, the prognostic significance of ras gene mutations in patients with these disorders has been a controversial issue. Altho
Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi