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Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum

✍ Scribed by J.Werner Zolg; James R. Plitt; Guo-Xian Chen; Sandy Palmer


Book ID
113260575
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
744 KB
Volume
36
Category
Article
ISSN
0166-6851

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Two mutations in dihydrofolate reductase
✍ Ambrose O. Talisuna; Anne Nalunkuma-Kazibwe; Peter Langi; Theonest K. Mutabingwa 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 87 KB

The point mutations in the Plasmodium falciparum dihydrofolate reductase (dhfr) and the dihydropteroate synthase (dhps) genes that are linked to sulphadoxine-pyrimethamine (SP) resistance in vitro have been well characterised. To determine whether a few of these mutations could predict SP treatment