๐”– Bobbio Scriptorium
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Point mutations in human neoplasia

โœ Scribed by Stanley R. Hamilton; Bert Vogelstein


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
205 KB
Volume
154
Category
Article
ISSN
0022-3417

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The gene for the alpha polypeptide chain (alpha s) of the heterotrimeric G protein Gs can be activated to the putative oncogene gsp by specific point mutations at codons 201 and 227. Such mutations have been reported in 40% of human growth hormone-secreting pituitary adenomas and in a single autonom