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Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

✍ Scribed by Romeo, Giovanni; Ronchetto, Patrizia; Luo, Yin; Barone, Virginia; Seri, Marco; Ceccherini, Isabella; Pasini, Barbara; Bocciardi, Renata; Lerone, Margherita; Kääriäinen, Helena


Book ID
109787530
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
252 KB
Volume
367
Category
Article
ISSN
0028-0836

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Mutations of the RET proto-oncogene in t
✍ Charis Eng; Lois M. Mulligan 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 225 KB 👁 2 views

## Communicated by Martin Bobrow The RET proto-oncogene codes for a receptor tyrosine kinase thought to play a role in the development of neural crest and its derivatives. Mutations in the RET proto-oncogene have been found in patients with the multiple endocrine neoplasia type 2 syndromes (MEN 2)