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Point mutation increases a form of the NK1 receptor with high affinity for neurokinin A and B and septide

✍ Scribed by Alessandra Ciucci; Carla Palma; Stefano Manzini; Thomas M Werge


Book ID
110003838
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
322 KB
Volume
125
Category
Article
ISSN
0007-1188

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A novel series of arylpiperazines with h
✍ P. John Murray; Lee A. Harrison; Martin R. Johnson; Graeme M. Robertson; David I πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 210 KB

A novel series of arylpiperazines has been synthesised which show high affinity for dopamine D 3 receptors. Several of these compounds exhibit ca. 100 fold selectivity for the dopamine D 3 receptor over D 1 , D 2 and D 4 receptors. In vivo studies suggest that 4 (GR103691) may have an atypical antip