PO-79 Stable overexpression and knockdown of TFPI in breast cancer cells suggest antitumor properties of TFPI

Overexpression of both TFPIα and TFPIβ i

Overexpression of both TFPIα and TFPIβ induces apoptosis and expression of genes involved in the death receptor pathway in breast cancer cells

✍ Benedicte Stavik; Grethe Skretting; Marit Sletten; Per Morten Sandset; Nina Iver 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 391 KB

## Abstract Thrombosis is a major complication and an important cause of death in cancer patients. Tumor cells may trigger coagulation and induce a prothrombotic phenotype, which in return may enhance angiogenesis, tumor growth, and metastasis. Tissue factor pathway inhibitor (TFPI) has been report