✦ LIBER ✦

Pneumococcal Vaccination: The Response of Patients with Alcoholic Liver Cirrhosis

✍ Scribed by Mauro Pirovino; Eva Lydick; Peter J. Grob; Stephan Arrenbrecht; Josef Altorfer; Martin Schmid

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 349 KB
Volume: 4
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840040527

No coin nor oath required. For personal study only.

✦ Synopsis

Patients with cirrhosis have an increased risk of dying from pneumococcal pneumonia. Their immunological response to pneumococcal vaccination is not known. We compared the antibody response to challenge with a 14-valent purified pneumococcal polysaccharide vaccine in 15 patients with biopsy-proven alcoholic liver cirrhosis, 10 healthy volunteers and 10 patients with chronic obstructive pulmonary disease. Preimmunization levels for Danish type 1 pneumococcal polysaccharide were lower among cirrhotics than patients with chronic obstructive pulmonary disease. Four and 12 weeks after immunization, no significant differences were found in antibody concentrations between the three groups. We conclude that patients with alcoholic cirrhosis can produce an adequate antibody response to pneumococcal polysaccharide antigen.

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