On the influence of protein binding on p
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Leonid M. Berezhkovskiy
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Article
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2010
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John Wiley and Sons
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English
β 204 KB
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The effect of variable protein binding (taken as independent parameter) on pharmacological activity of drugs is considered in terms of the exposure or the steady state concentration of unbound drug at targeted tissue. Based on the application of the parallel tube or dispersion models it is shown tha