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PNA synthesis using a novel Boc/acyl protecting group strategy

✍ Scribed by Thomas Kofoed; Henrik F. Hansen; Henrik Ørum; Troels Koch

Book ID
105360146
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
185 KB
Volume
7
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

The synthesis of novel Boc/acyl protected monomers for the synthesis of peptide nucleic acid (PNA) is described. The oligomerization protocol using these new monomers has been optimized with regard to coupling reagents. The use of base‐labile acyl protecting groups at the exocyclic amines of the heterocyclic bases (isobutyryl for guanine and benzoyl for adenine and cytosine) and a PAM‐linked solid support offers an attractive alternative to the present procedures used in PNA synthesis. This strategy has been applied for the synthesis of a test 17mer PNA on both control pore glass (CPG) and a polystyrene MBHA support and was used in the preparation of PNA–DNA chimeras. Copyright © 2001 European Peptide Society and John Wiley & Sons, Ltd.

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