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PML-RARα inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia

✍ Scribed by Kazunori Ohnishi

Book ID: 106284995
Publisher: Springer
Year: 2007
Tongue: English
Weight: 244 KB
Volume: 12
Category: Article
ISSN: 1341-9625
DOI: 10.1007/s10147-007-0694-6

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## Abstract Acute promyelocytic leukemia (APL) cells are characterized by PML/RARα fusion protein, high responsiveness to arsenic trioxide (ATO)‐induced cytotoxicity and an abundant generation of reactive oxygen species (ROS). In this study we investigated the association among these three features