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PML a target of translocations in APL is a regulator of cellular senescence

✍ Scribed by Ferbeyre, G


Book ID
110055279
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
153 KB
Volume
16
Category
Article
ISSN
0887-6924

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By using differential display, we cloned the human counterpart of the murine gene Hic-5 from senescent human keratinocytes. The full-length cDNA contained a short GC-stretch proceeding a consensus Kozak sequence followed by a single open reading frame of 1338 bp encoding a 461Β±amino acid protein wit