Plutonium-237 labelling: A new technique for plutonium metabolic studies in animals

Addressing the metabolic activation pote

Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques

✍ Koppara Samuel; Wenji Yin; Ralph A. Stearns; Yui S. Tang; Ashok G. Chaudhary; Ja 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 180 KB

## Abstract Metabolic activation of drug candidates to electrophilic reactive metabolites that can covalently modify cellular macromolecules may result in acute and/or idiosyncratic immune system‐mediated toxicities in humans. This presents a significant potential liability for the future developme