## Abstract One of the most contentious issues in biology today concerns the existence of stem cell plasticity. The term โplasticityโ refers to the capacity of tissueโderived stem cells to exhibit a phenotypic potential that extends beyond the differentiated cell phenotypes of their resident tissue
Pluripotent plasticity of stem cells and liver repopulation
โ Scribed by Luisa Gennero; Maria Augusta Roos; Kirk Sperber; Tetyana Denysenko; Paola Bernabei; Gian Franco Calisti; Mauro Papotti; Susanna Cappia; Roberto Pagni; Giuseppe Aimo; Giulio Mengozzi; Giovanni Cavallo; Stefano Reguzzi; Gian Piero Pescarmona; Antonio Ponzetto
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 145 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0263-6484
- DOI
- 10.1002/cbf.1630
No coin nor oath required. For personal study only.
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## Abstract Considerable hope surrounds the use of diseaseโspecific pluripotent stem cells to generate models of human disease allowing exploration of pathological mechanisms and search for new treatments. Diseaseโspecific human embryonic stem cells were the first to provide a useful source for stu
Liver-directed gene therapy is appropriate for many conditions. Recent work established that liver repopulation with transplanted cells can be effective in treating genetic disorders. Although hepatocytes express therapeutic genes with considerable efยฎciency, correction of genetic disorders is const