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PLTP regulates STAT3 and NFκB in differentiated THP1 cells and human monocyte-derived macrophages

✍ Scribed by S. Vuletic; W. Dong; G. Wolfbauer; C. Tang; J.J. Albers

Book ID
113486490
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
867 KB
Volume
1813
Category
Article
ISSN
0167-4889

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## Abstract The transcription factor NFκB plays a key role in the tissue inflammatory response. Metal ions released into tissues from biomaterials (e.g., Au, Pd, Ni, Hg) are known to alter the binding of NFκB proteins to DNA, thereby modulating the effect of NFκB on gene activation and, ultimately,