## Abstract Hepatitis C Virus (HCV) is classified into six genotypes. Genotype 4 is now spreading in Europe, especially among drug users, who are often infected with both HCV and the human immunodeficiency virus (HIV). Previous studies have shown that HCVโ4 responds poorly to interferon. Pegylated
Pleural effusion associated with pegylated interferon alpha and ribavirin treatment for chronic hepatitis C
โ Scribed by Amit Arora; Leonardo Vargas; Tomasz J. Kuzniar
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 128 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1553-5592
- DOI
- 10.1002/jhm.452
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
Lung toxicity related to interferon (IFN) alpha typically takes a form of interstitial pneumonitis, granulomatous inflammation, or organizing pneumonia. We report a case of a 52โyearโold woman, who developed pneumonitis with exudative, lymphocyticโpredominant pleural effusion following treatment with pegylated IFN alpha and ribavirin for hepatitis C. Her symptoms and lung findings resolved over 3 months of observation without corticosteroid therapy. Journal of Hospital Medicine 2009;4:E45โE46. ยฉ 2009 Society of Hospital Medicine.
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accurate representation of the data is given in Table 1. 7. The major conclusion of this paper was that monitoring hepatitis C virus RNA levels and varying the duration of therapy can save resources without sacrificing rates of SVR. The authors used the Blackwelder test to test the noninferiority of
Randomized controlled trials of hepatitis C virus (HCV) therapy with pegylated interferon and ribavirin have demonstrated sustained viral response rates (SVRs) of 54%-63% (efficacy). Treatment results in clinical practice (effectiveness) may not be equivalent. The goal of this study was to assess th
This study was partially supported by grants UBACYT M055 (Universidad de Buenos Aires) and PICT 06-124 (Agencia Nacional de Promocioยดn Cien-tฤฑยดfica y Tecnoloยดgica).
Up to 50% of patients with chronic hepatitis C fail to respond to initial therapy with pegylated interferon (PEG-IFN) and ribavirin (RBV). With unsuccessful viral eradication, these patients remain at risk for developing progression of their liver disease. Retreatment with PEG-IFN/RBV yields sustain