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Plerixafor induces the rapid and transient release of stromal cell-derived factor-1 alpha from human mesenchymal stromal cells and influences the migration behavior of human hematopoietic progenitor cells

✍ Scribed by Wuchter, Patrick; Leinweber, Christina; Saffrich, Rainer; Hanke, Maximilian; Eckstein, Volker; Ho, Anthony D.; Grunze, Michael; Rosenhahn, Axel


Book ID
121553904
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
683 KB
Volume
355
Category
Article
ISSN
0302-766X

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Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine produced by stromal cells that acts as a chemoattractant for human CD34 + progenitor cells. We investigated the expression of CXCR4, the receptor for SDF-1, on CD34 + cells from different hematopoietic sites and developmental stages. CXCR4 was