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Plenary lecture Mechanism of signal transduction in mast cells and basophils: Studies with RBL-2H3 cells

✍ Scribed by M. A. Beaven; K. Maeyama; E. WoldeMussie; T. N. Lo; H. Ali; J. R. Cunha-Melo

Publisher
SP Birkhäuser Verlag Basel
Year
1987
Tongue
English
Weight
744 KB
Volume
20
Category
Article
ISSN
1420-908X

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✍ Kazutaka Maeyama; Masayuki Sasaki; Takehiko Watanabe 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 874 KB

In rat basophilic leukemia cells (RBL-2H3), a tumor analogue of mast cells, the aggregation of IgE receptors initiates increase in the intracellular concentration of calcium ([Ca2+]i), monitored with the fluorescent Ca probe fura-2, and finally results in histamine secretion. In cell suspensions, ho