Pleiotrophin: A Cytokine with Diverse Functions and a Novel Signaling Pathway
β Scribed by Thomas F. Deuel; Nan Zhang; Hsui-Jen Yeh; Inmaculada Silos-Santiago; Zhao-Yi Wang
- Book ID
- 115569092
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 198 KB
- Volume
- 397
- Category
- Article
- ISSN
- 0003-9861
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Identification of Pygopus in __Drosophila__ as a dedicated component of the Wg (fly homolog of mammalian Wnt) signaling cascade initiated many inquiries into the mechanism of its function. Surprisingly, the nearly exclusive role for Pygopus in Wg signal transduction in flies is not seen
Recent findings have significantly advanced our understanding of the mechanism by which the potent immunosuppressive drug rapamycin inhibits cytokine-dependent lymphocyte proliferation. The protein targeted by the immunophilin-rapamycin complex is a member of a newly defined family of phosphoinositi