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PLCζ(zeta): A sperm protein that triggers Ca2+ oscillations and egg activation in mammals

✍ Scribed by K. Swann; C.M. Saunders; N.T. Rogers; F.A. Lai

Book ID: 116881218
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 290 KB
Volume: 17
Category: Article
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2006.03.009

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## Abstract We have discovered that a single sperm protein, phospholipase C‐zeta (PLCζ), can stimulate intracellular Ca^2+^ signalling in the unfertilized oocyte (‘egg’) culminating in the initiation of embryonic development. Upon fertilization by a spermatozoon, the earliest observed signalling ev