✦ LIBER ✦

Playing with bone and fat

✍ Scribed by Jeffrey M. Gimble; Sanjin Zvonic; Z. Elizabeth Floyd; Moustapha Kassem; Mark E. Nuttall

Book ID: 102302734
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 195 KB
Volume: 98
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.20777

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The relationship between bone and fat formation within the bone marrow microenvironment is complex and remains an area of active investigation. Classical in vitro and in vivo studies strongly support an inverse relationship between the commitment of bone marrow‐derived mesenchymal stem cells or stromal cells to the adipoctye and osteoblast lineage pathways. In this review, we focus on the recent literature exploring the mechanisms underlying these differentiation events and discuss their implications relevant to osteoporosis and regenerative medicine. J. Cell. Biochem. 98: 251–266, 2006. © 2006 Wiley‐Liss, Inc.

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