(−)-Platynecine, a pyrrolizidine necine base
✍ Scribed by Freer, A. A. ;Kelly, H. A. ;Robins, D. J.
- Book ID
- 114504493
- Publisher
- International Union of Crystallography
- Year
- 1987
- Tongue
- English
- Weight
- 324 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0108-2701
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📜 SIMILAR VOLUMES
&one&z (l\_), a hepfitinenAative necine base ad hepatoLotic and catroinog~tic py~~~oLLz~&ne aLkaLoL&, ~a6 nyntienized -in ~~~cemic dam #om eXhq1 I-hydtloxy-2,3,5,6-&&ahq&o-TH-pqwcoLLz~iu-7-catrboxy~~e (21.
Synthesis of (1α,7α,8β)‐(±)‐7‐Hydroxy‐1‐(hydroxymethyl)pyrrolizidin, the Necine __rac__‐Platynecine __rac__‐Platynecine (__rac__‐7) can easily be obtained in high yields from diethyl (±)‐__cis__‐2,3‐pyrrolidinedicarboxylate (__rac__‐1) by __N__‐alkylation to ethyl (±)‐__cis__‐2,3‐bis(ethoxycarbonyl
Molecular mechanics calculations were applied to the Ž . conformational analysis of two diasteroisomers, the pyrrolizidine alkaloids PAs retronecine and heliotridine. The application of reoptimized parameters for H Ž . bonding corrected the tendency of MM3 92 calculations to give unrealistic H иии O
The structural stabilities of endo and exo conformations of retronecine and heliotridine molecules were analyzed using different ab initio, semiempirical, and molecular mechanics methods. All electron and pseudopotential ab initio calculations at the Hartree-Fock level of theory with 6-31G\* and CEP