Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells
โ Scribed by Mun-Ock Kim; Dong-Oh Moon; Yung Hyun Choi; Dong Yeok Shin; Ho Sung Kang; Byung Tae Choi; Jae-Dong Lee; Wei Li; Gi-Young Kim
- Book ID
- 116334588
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 290 KB
- Volume
- 261
- Category
- Article
- ISSN
- 0304-3835
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## Abstract Platycodin D (PD), a major constituent of triterpene saponins in __Platycodon grandiflorum__, has also become an interesting candidate for cancer chemotherapy; however, little is known about apoptotic mechanisms on cancer cells. We herein investigated the mechanisms that are related to
## Abstract Ribozyme possesses specific endoribonuclease activity and catalyzes the hydrolysis of specific phosphodiester bonds, which results in the cleavage of target RNA sequences. Here, we evaluated the ability of hammerhead ribozymes targeting human telomerase RNA (hTR) to inhibit the catalyti