Platinum(II)-Catalyzed Intramolecular Cyclization of o-Substituted Aryl Alkynes through sp3 CH Activation

✍ Scribed by Shangdong Yang; Zigang Li; Xing Jian; Chuan He

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 308 KB
• Volume: 48
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200900368

✦ Synopsis

Abstract

Ring leader: PtCl~2~ catalyzes intramolecular cyclization of o‐isopropyl or o‐benzyl aryl alkynes to give substituted indene derivatives with good yields and high selectivity. This reaction appears to proceed through an sp^3^ CH activation and 1,4‐hydrogen migration pathway (see scheme).magnified image