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Platinum-catalyzed exchange labelling of representative organic compounds with tritium gas or tritiated water

✍ Scribed by Philip G. Williams; Christopher A. Lukey; Mervyn A. Long; John L. Garnett

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 777 KB
Volume: 29
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580290208

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✦ Synopsis

A wide range of simple organic substrates has been successfully tritium labelled using reduced platinum oxide as catalyst. Exchange conditions involved reaction temperatures in the range 60-15OoC, and reaction times of 3-7 days. The isotope sources for the reactions were tritium gas and tritiated water. Analysis of the labelled products was accomplished by radio-glc and by 3H NMR spectroscopy. The specific activities ranged up to 1100 mCi/mL, and most of the labelled products showed high radiochemical purity. The regioselectivity of tritium incorporation, as obtained from 3H NMR studies, supports currently accepted theories for mechanisms of platinum-catalyzed hydrogen isotope exchange. The results also show remarkable consistency for a heterogeneous system under widely varying reaction conditions.

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