Platinum-Catalysed Cyclopropanation of Olefins with Ethyl Diazoacetate

✍ Scribed by S. Boverie; F. Simal; A. Demonceau; A.F. Noels; I.L. Eremenko; A.A. Sidorov; S.E. Nefedov

• Book ID: 104258140
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 606 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)10027-2

✦ Synopsis

The addition of ethyl diazoacetate to olefins in the presence of a cataiytic amount of platinum complexes provides the corresponding cyclopropanes in good to excellent yields. 0 1997Published E S L Functionalized cyclopropanes provide building blocks of unprecedented synthetic potential. Moreover, natural or synthetic cyclopropanes bearing simple furtctionalities (hydroxy-, amino-, carboxylic-, l-hydroxycarboxylic or l-aminocarboxylic acids, nucleosides, ...) are endowed with a large spectrum of biological properties, ranging from antibiotic, antiviral, antifungal, insecticidal, hormonal, neurochemical, carcinogenic or antitomoral activities, to plant growth and fruit ripening controls, enzyme and gluconeogenesis inhibitions.1