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Platinum anticancer agents and antidepressants: desipramine enhances platinum-based cytotoxicity in human colon cancer cells

โœ Scribed by Peyman Kabolizadeh; Brigitte J. Engelmann; Nicholas Pullen; Jennifer K. Stewart; John J. Ryan; Nicholas P. Farrell


Book ID
106232623
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
524 KB
Volume
17
Category
Article
ISSN
1432-1327

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## Abstract We have investigated the comparative initial DNA binding properties of 7 platinumโ€based anticancer drugs: 5 __cis__โ€oriented compounds, cisplatin, tetraplatin (Ormaplatin), JM118 [__cis__ ammine dichloro (cyclohexylamine) platinum (II)], JM216 [bisโ€acetato __cis__ ammine dichloro (cyclo