No coin nor oath required. For personal study only.
Objective: A blinded, crossover, placebo-controlled study of the effectiveness of the ketogenic diet (KGD). Methods; 20 children with Lennox Gastaut Syndrome, having Ͼ15 EEG documented seizures/d were fasted for 36 hrs, and KGD introduced. Glucose or saccharine was added in randomized, blinded fashion to negate (placebo) or sustain the effect of the diet (treatment). Patients were evaluated after 5 days in each arm with a fast in-between. Parental seizure detections (PS) and EEG seizures (ES) were assessed. Results: The group median for ES went from 20 (1,149) to 6(0,507) for placebo to treatment, from 11(0,233) to 11(0,44) for treatment to placebo. The group median of PS went from 11 (3,75) to 7 (0, 52) for placebo to treatment, from 8 (0,37) to 15 (0,18) for treatment to placebo. There was no significant difference between the two arms in number of ES (pϭ0.7) and marginal difference in PS (pϭ0.07). There was significant reduction in median seizures overall (30 to 10 seizures/ day, p Ͻ 0.0001) between baseline and introduction of the diet. No patient had absent betahydroxybutyrate during the glucose arm. Conclusions: The initial fasting to start the KGD was followed by a significant seizure reduction. The randomized component of the trial showed no reduction in EEG-identified, but moderate statistical evidence for a reduction in parent-identified seizures. Administration of 60 grams of glucose/d did not completely eliminate ketones, and may not counter the original effects of fasting.
📜 SIMILAR VOLUMES