Platelet Proteomics: Principles, Analysis, and Applications (Wiley - Interscience Series on Mass Spectrometry)

✍ Scribed by Angel Garcia-Alonso, Yotis Senis

• Publisher: Wiley
• Year: 2011
• Tongue: English
• Leaves: 412
• Series: Interscience Series on Mass Spectrometry
• Edition: 1
• Category: Library

✦ Synopsis

The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics.  This chapter shows potential applications for platelet proteomics not yet carried out.  It includes examples of post-translational modifications (PTMs) analysis in platelets.The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease.  This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.

✦ Table of Contents

cover.jpg......Page 0
fmatter.pdf......Page 1
ch1.pdf......Page 19
ch2.pdf......Page 44
ch3.pdf......Page 83
ch4.pdf......Page 103
ch5.pdf......Page 126
ch6.pdf......Page 153
ch7.pdf......Page 172
ch8.pdf......Page 198
ch9.pdf......Page 220
ch10.pdf......Page 242
ch11.pdf......Page 263
ch12.pdf......Page 295
ch13.pdf......Page 331
ch14.pdf......Page 351
index.pdf......Page 390