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Platelet protein phosphorylation and protein kinase C activation by phorbol esters with different biological activity and a novel synergistic response with Ca2+ ionophore

✍ Scribed by Susan F. BROOKS; Philip C. GORDGE; Alex TOKER; A. Tudor EVANS; Fred J. EVANS; Alastair AITKEN


Book ID
115127765
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
788 KB
Volume
188
Category
Article
ISSN
1432-1327

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The effects of phorbol esters on Ca 2 + channel currents in human neuroblastoma SH-SY5Y cells were studied using whole-cell patch-clamp recordings. Bath application of 12-O-tetradecanoylphorbol-13-acetate (TPA) or phorbol 12, 13-dibutyrate (PDBu; 100 nM to 1 #M), known activators of protein kinase C