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Platelet paroxetine binding in major depressive disorder with and without comorbid obsessive-compulsive disorder

โœ Scribed by Elliot C. Nelson; Yvette I. Sheline; Mark E. Bardgett; Jamie L. Jackson; John G. Csernansky


Book ID
119095922
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
901 KB
Volume
58
Category
Article
ISSN
0165-1781

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Platelet [3H]-paroxetine binding was analysed in 26 patients (13F, 13M) with obsessive compulsive disorder and 26 normal controls (I 3F, 13M). For patients with obsessive compulsive disorder, B, , , was 2127 f 480 fmoYmg protein (mean f SD) compared to control Bmax values of 1926 f 696 fmoVmg protei

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Previous findings suggested a unique role that depression symptoms might play in the comorbid relationship between obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). However, the nature of this role remains unclear. Thus, the current study examined ways in which OCD and PT