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Platelet-neutrophil interaction and superoxide anion generation: Involvement of purine nucleotides

✍ Scribed by Susanna Colli; Sonia Eligini; Mariagrazia Lalli; Elena Tremoli


Book ID
113386757
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
715 KB
Volume
20
Category
Article
ISSN
0891-5849

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We examined the effects of okadaic acid, a protein phosphatase 1 and 2A inhibitor, on superoxide generation in human neutrophils. Superoxide generation induced by fMLP was inhibited by low-dose okadaic acid (1 0-1 00 nM), but it had no effect on superoxide synthesis by PMA, and the fMLP-induced rise