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Platelet hypersensitivity induced by 1-chloro-2,4-dinitrobenzene, hydroperoxides and inhibition of lipoxygenase

โœ Scribed by Timothy D. Hill; James G. White; Gundu H.R. Rao


Book ID
119037454
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
598 KB
Volume
53
Category
Article
ISSN
0049-3848

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Clotrimazole, a specific inhibitor of the Ca 2+ activated potassium (Gardos) channel, and the antioxidant N-acetylcysteine were found to inhibit the in vitro formation of highdensity sickle cells induced by treatment with 1-chloro-2,4-dinitrobenzene (CDNB). The CDNB induced leakage of K + can be inh