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Platelet-Derived Growth Factor Increases the Activity of the Promoter of the Insulin-like Growth Factor-1 (IGF-1) Receptor Gene

✍ Scribed by Michele Rubini; Haim Werner; Enrico Gandini; Charles T. Roberts Jr.; Derek LeRoith; Renato Baserga

Book ID
115601707
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
453 KB
Volume
211
Category
Article
ISSN
0014-4827

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## Abstract Integrin receptors bind extracellular matrix proteins, and this link between the cell membrane and the surrounding matrix may translate skeletal loading to biologic activity in osteoprogenitor cells. The interaction between integrin and growth factor receptors allows for mechanically in