Platelet-derived growth factor has been shown to play an important role in the repair process after acute tissue injury and in the pathogenesis of several fibrogenic disorders. The aim of this study was to evaluate whether increased expression of platelet-derived growth factor and its p-receptor sub
Platelet-derived growth factor expression in a transgenic model
β Scribed by Fries, Jochen W U; Collins, Tucker
- Book ID
- 109882312
- Publisher
- Nature Publishing Group
- Year
- 1992
- Tongue
- English
- Weight
- 676 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0085-2538
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## Background: Angiogenesis is a prerequisite to cancer growth and metastasis and is induced by a variety of angiogenic factors, including platelet-derived endothelial cell growth factor (pdecgf). the authors investigated the expression of pdecgf in 58 initial primary bladder carcinomas. ## Method
Platelet-derived growth factor (PDGF) is a 30 kDa protein consisting of disulfide-bonded dimers of Aand B-chains. PDGF receptors are of two types, a-and @-receptors, which are members of the protein-tyrosine kinase family of receptors. The receptors are activated by ligand-induced dimerization, wher