Platelet consumption by polyvinyl alcohol coated tubing in canines

✍ Scribed by Ip, W. F. ;Sefton, M. V.

• Book ID: 102871939
• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 693 KB
• Volume: 25
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820250707

✦ Synopsis

Polyvinyl alcohol (PVA)-coated polyethylene tubing, with or without immobilized heparin, caused severe thrombocytopenia and enhanced the production of new platelets when inserted in a chronic arteriovenous shunt in canines. A similar length of uncoated polyethylene tubing neither lead to thrombocytopenia nor significantly enhanced platelet regeneration, relative to the shunt only without a test section. Platelet regeneration was monitored by the malondialdehyde assay, which was assumed to make a distinction between "new" and " o l d platelets. This distinction was combined with the platelet count values to enable calculation of the cumulative consumption curve and the initial fractional consumption rate in the presence of a non constant platelet count. The resulting initial fractional consumption rates were: 34%/day for PVA, 20.5%/day for polyethylene, and 18%/day for the shunt only blank. 17.

19. G. Llanos (unpublished observations).