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Platelet C4d is highly specific for systemic lupus erythematosus

✍ Scribed by Jeannine S. Navratil; Susan Manzi; Amy H. Kao; Shanthi Krishnaswami; Chau-Ching Liu; Margie J. Ruffing; Penny S. Shaw; Abbey C. Nilson; Emily R. Dryden; Jeffrey J. Johnson; Joseph M. Ahearn


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
97 KB
Volume
54
Category
Article
ISSN
0004-3591

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## Abstract ## Objective C4‐derived activation fragments are the only complement ligands present on the surfaces of normal erythrocytes. The significance of this observation is unknown, and the role of erythrocyte‐bound C4 (E‐C4) in human disease has not been explored. More than any other human di

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In a study of 59 black American patients with systemic lupus erythematosus (SLE), we found that partial C4A deficiency occurred twice as frequently as in 59 control subjects (32.3% versus 15.3%; P = 0.02). Complete C4A deficiency, however, occurred in only 1 patient and in no controls. Partial C4A

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## Abstract ## Objective There is an important inflammatory component to atherosclerosis and cardiovascular disease (CVD). It is therefore interesting that the risk of CVD is high in inflammatory diseases such as systemic lupus erythematosus (SLE). In this study, we investigated nontraditional ris