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Platelet Activating Factor Stimulates Sodium-Proton Exchange

✍ Scribed by Ajiro, Yoichi; Saegusa, Noriko; Iwade, Kazunori; Giles, Wayne R.; Stafforini, Diana; Spitzer, Kenneth W.


Book ID
122744245
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
41 KB
Volume
102
Category
Article
ISSN
0006-3495

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The effects of platelet-activating factor (PAF) on Na(+)-dependent calcium uptake in myocardial sarcolemmal vesicles were examined in order to clarify its mechanism of inotropic action on the heart. PAF (40 and 20 microM) significantly inhibited Na(+)-Ca2+ exchange by 61% and 37%, respectively. Both