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Platelet-activating factor-induced loss of vascular responsiveness to noradrenaline in pithed rats: involvement of nitric oxide

โœ Scribed by Tatsuya Shiga; Daisuke Yoshikawa


Book ID
115890330
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
516 KB
Volume
282
Category
Article
ISSN
0014-2999

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Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) and inflammatory substances (e.g., platelet-activating factor [PAF]) is a key contributor to the pathophysiological outcomes observed in the liver during sepsis. In rats subjected to liver-focused endotoxe