Platelet-activating factor antagonists protect amyloid-β damaged neurons from microglia-mediated death

Tripchlorolide protects neuronal cells f

Tripchlorolide protects neuronal cells from microglia-mediated β-amyloid neurotoxicity through inhibiting NF-κB and JNK signaling

✍ Xiao-Dong Pan; Xiao-Chun Chen; Yuan-Gui Zhu; Li-Min Chen; Jing Zhang; Tian-Wen H 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 473 KB

Recent research has focused on soluble oligomeric assemblies of beta-amyloid peptides (Abeta) as the proximate cause of neuroinflammation, synaptic loss, and the eventual dementia associated with Alzheimer's disease (AD). In this study, tripchlorolide (T4), an extract of Tripterygium wilfordii Hook.