Synovial fluid (SF) and synovial tissue from 10 patients with juvenile rheumatoid arthritis were examined. The SFs were heterogeneous with respect to the degree of complement activation. Quantification of C3dg and the terminal complement complex revealed a positive correlation between activation of
Platelet-activating activity in synovial fluids of patients with rheumatoid arthritis, juvenile rheumatoid arthritis, gout, and noninflammatory arthropathies
โ Scribed by Christine Shapleigh; Frank H. Valone; Peter H. Schur; Edward J. Goetzl; Dr. K. Frank Austen
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 723 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0004-3591
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A cofactor that selectively opsonizes particulate activators of the human alternative complement pathway and enhances their phagocytosis by human monocytes was identified in synovial fluids of patients with rheumatoid arthritis. The active material was present in fluids treated with protease inhibit
## Abstract Analyses of CH50, complement components, properdin factors, and kininogen in synovial fluid of patients with juvenile rheumatoid arthritis revealed evidence of activation of the classic complement pathway in all clinical subgroups. Juveniles with the adult pattern of disease had the gre