Plasticization of aqueous poly(vinyl alcohol) and hydroxypropyl methylcellulose with polyethylene glycols and glycerol

✍ Scribed by P. Sakellariou; A. Hassan; R.C. Rowe

• Publisher: Elsevier Science
• Year: 1993
• Tongue: English
• Weight: 527 KB
• Volume: 29
• Category: Article
• ISSN: 0014-3057
• DOI: 10.1016/0014-3057(93)90289-r

✦ Synopsis

The plasticization of aqueous hydroxypropyl methylcellulose (HPMC) and poly(vinyl alcohol) (PVA) with poly(ethylene glycols) (PEGs) with various molecular weights and with glycerol has been investigated. The plasticizing efficiency in the case of HPMC was: PEG200 > PEG400 > GLYCEROL > PEG6000 and for PVA: GLYCEROL > PEG200 > PEG400 > PEG6000. The plasticizer efficiency rating was explained with the partial solubility parameters of the polymers and the plasticizers in terms of the propensity of each polymer-plasticizer pair to set up polar and hydrogen-bonding interactions. Phase separation of the plasticizers occurred above a critical concentration which, in the case of PEGs, was inversely proportional to molecular weight. Phase separation of the plasticizer was shown to be responsible for deterioration in the plasticizing efficiency.